Sugi Predict

Sugi Predict / Compounds / SCHEMBL8891920

SCHEMBL8891920

SCHEMBL8891920

CC(C)(C)OC(=O)N1CCOC(CCCO)C1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ RECQL P46063 1/20 0.43
▸ NR1H2 P55055 1/20 0.43
▸ MAPT P10636 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ EPHA2 P29317 4/20 0.39
▸ PDK1 Q15118 4/20 0.39
▸ ERBB2 P04626 1/20 0.37
▸ EPHB4 P54760 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ THRB P10828 1/20 0.37
▸ FAAH O00519 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18259604 1.00 USP2 (0.48) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL20516006 1.00 USP2 (0.48) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL1655537 0.92 USP2 (0.50) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL31040994 0.92 USP2 (0.50) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL18669262 0.88 USP2 (0.47) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL20913885 0.88 USP2 (0.47) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL18689545 0.88 USP2 (0.47) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL23877994 0.86 USP2 (0.50) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL22168315 0.86 USP2 (0.50) USP2SMN1; SMN2RECQLNR1H2MAPT
SCHEMBL8904969 0.86 USP2 (0.53) USP2SMN1; SMN2RECQLNR1H2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108884083-B Benzo [ B ] furans as bromodomain inhibitors 葛兰素史克知识产权第二有限公司 2022-02-25 — — CN disclosed
CN-108137541-B Pyridone dicarboxamides for use as bromodomain inhibitors 葛兰素史克知识产权第二有限公司 2021-07-06 — — CN disclosed
CN-108884070-B Pyridyl derivatives as bromodomain inhibitors 葛兰素史克知识产权第二有限公司 2021-07-02 — — CN disclosed
US-10934272-B2 Pyridyl derivatives as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2021-03-02 — — US disclosed
EP-3440069-B1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-10-28 — — EP disclosed
EP-3122747-B1 DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS NORTH & SOUTH BROTHER PHARMACY INVESTMENT CO LTD (CN) 2020-05-20 — — EP disclosed
US-10583112-B2 Benzo[b]furans as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2020-03-10 — — US disclosed
EP-3440075-B1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-01-29 — — EP disclosed
US-10370356-B2 Pyridinone dicarboxamide for use as bromodomain inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-08-06 — — US disclosed
US-20190151279-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-05-23 — — US disclosed
US-20190119248-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2019-04-25 — — US disclosed
US-20180282301-A1 PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2018-10-04 — — US disclosed
US-9771358-B2 Dihydropyrimidine compounds and their application in pharmaceuticals SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-09-26 — — US disclosed
US-20160347746-A1 DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-12-01 — — US disclosed
WO-1997043292-A1 NEW THIAZOLOPYRIDINES KLINGE PHARMA GMBH (DE) 1997-11-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10370356-B2 Pyridinone dicarboxamide for use as bromodomain inhibitors BRD4, BRD3, BRDT USP2 2296/4885SMN1; SMN2 3293/4885RECQL 883/4885
US-10934272-B2 Pyridyl derivatives as bromodomain inhibitors BRD4, BRD3, BRDT USP2 2873/4885SMN1; SMN2 3654/4885RECQL 852/4885
US-10583112-B2 Benzo[b]furans as bromodomain inhibitors BRD4, BRD3, BRD2 USP2 1891/4885SMN1; SMN2 3232/4885RECQL 1030/4885
US-20160347746-A1 DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS DPYD, SLC10A1, HPRT1 USP2 4117/4885SMN1; SMN2 1778/4885RECQL 509/4885
US-20190119248-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRDT USP2 2873/4885SMN1; SMN2 3654/4885RECQL 852/4885
US-20190151279-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRD2 USP2 1891/4885SMN1; SMN2 3232/4885RECQL 1030/4885
US-20180282301-A1 PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS BRD4, BRD3, BRDT USP2 2296/4885SMN1; SMN2 3293/4885RECQL 883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.