Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 5/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BMP4 | P12644 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759418 | 0.90 | MAP2K1 (0.51) | HRH3HRH2HRH1RETPRKAB2 | |
| SCHEMBL29631255 | 0.82 | RET (0.37) | RETDRD2DRD1DRD4HTR2A | |
| SCHEMBL30175349 | 0.81 | CYP11B1 (0.41) | RETDRD2DRD1DRD4HTR2A | |
| SCHEMBL30175296 | 0.81 | RET (0.45) | RET | |
| SCHEMBL30175294 | 0.81 | RET (0.43) | RETDRD2DRD1DRD4HTR2A | |
| SCHEMBL30175367 | 0.80 | RET (0.48) | RET | |
| SCHEMBL20070600 | 0.78 | RET (0.50) | RET | |
| SCHEMBL25252185 | 0.78 | CDK2 (0.36) | RETDRD2DRD1DRD4HTR2A | |
| SCHEMBL29566683 | 0.78 | RET (0.45) | RET | |
| SCHEMBL30175370 | 0.78 | CDK2 (0.36) | RETDRD2DRD1DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |