Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681976 | 0.83 | MAPT (0.55) | MAPTCYP1A2 | |
| SCHEMBL2681979 | 0.83 | MAPT (0.55) | MAPTCYP1A2 | |
| SCHEMBL26151977 | 0.81 | MAPT (0.48) | MAPTCYP1A2 | |
| SCHEMBL12740946 | 0.81 | ROCK2 (0.42) | ROCK2ROCK1GSK3BCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1448748 | 0.80 | ROCK2 (0.42) | ROCK2ROCK1GSK3BCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1448751 | 0.80 | ROCK2 (0.42) | ROCK2ROCK1GSK3BCYP1A2CYP3A4 | |
| SCHEMBL31398804 | 0.79 | ROCK2 (0.43) | ROCK2ROCK1GSK3BCYP1A2CYP3A4 | |
| SCHEMBL18152220 | 0.78 | ROCK2 (0.42) | KCNH2ROCK2ROCK1GSK3BCYP1A2 | |
| SCHEMBL18159371 | 0.78 | ROCK2 (0.42) | KCNH2ROCK2ROCK1GSK3BCYP1A2 | |
| SCHEMBL5473688 | 0.78 | HTR2C (0.47) | ROCK2ROCK1GSK3BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676547-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2026-01-14 | — | — | EP | disclosed |
| EP-4665331-A1 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024186584-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | WO | disclosed |
| WO-2024173219-A1 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |