Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | QRFPR | Q96P65 | 5/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | BLK | P51451 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528189 | 1.00 | ESR2 (0.46) | ESR2NR1H2QRFPRTBK1JAK2 | |
| SCHEMBL29867555 | 0.89 | ESR2 (0.48) | ESR2NR1H2TGFBR1ABL1HCK | |
| SCHEMBL20552990 | 0.89 | ESR2 (0.48) | ESR2NR1H2TGFBR1ABL1HCK | |
| SCHEMBL21528068 | 0.81 | MTOR (0.48) | TGFBR1ABL1 | |
| SCHEMBL31046941 | 0.81 | MTOR (0.48) | TGFBR1ABL1 | |
| SCHEMBL29867706 | 0.75 | PIK3CD (0.39) | JAK2JAK3SRC | |
| SCHEMBL23150435 | 0.75 | PIK3CD (0.43) | QRFPRJAK2JAK3SRCBLK | |
| SCHEMBL20553360 | 0.73 | MTOR (0.58) | TGFBR1ABL1 | |
| SCHEMBL20553303 | 0.72 | RET (0.48) | ESR2NR1H2JAK2JAK3TGFBR1 | |
| SCHEMBL20553139 | 0.72 | TGFBR1 (0.54) | JAK2PTK2TGFBR1ABL1HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |