Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107539 | 0.87 | DDT (0.46) | HRH3NPC1 | |
| SCHEMBL3109421 | 0.86 | EPHX2 (0.45) | HRH3NAMPTPTGER4EPHX2PPARG | |
| SCHEMBL3113914 | 0.78 | GLS (0.51) | NAMPTEPHX2 | |
| SCHEMBL3105042 | 0.71 | GLS (0.52) | LSS | |
| SCHEMBL17276548 | 0.69 | KLKB1 (0.47) | LSSTP53LMNAKCNH2P2RX7 | |
| SCHEMBL2629356 | 0.67 | LSS (0.59) | LSSP2RX7NAMPTMTORHDAC1 | |
| SCHEMBL24575984 | 0.66 | MTOR (0.69) | LSSNAMPTMTORHDAC1HDAC3 | |
| SCHEMBL17276449 | 0.66 | ALDH1A1 (0.55) | TP53HDAC1POLBHDAC3HDAC6 | |
| SCHEMBL12648418 | 0.66 | ASAH1 (0.54) | TP53LMNANAMPTPOLBHDAC6 | |
| SCHEMBL5464853 | 0.65 | MEN1 (0.70) | LSSKCNH2HRH3P2RX7NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803822-B2 | Triazole derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-28 | — | — | US | disclosed |