Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 9/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26892701 | 1.00 | EGLN2 (0.42) | EGLN2DDR2PGRARTP53 | |
| SCHEMBL26697649 | 0.86 | ALDH1A1 (0.43) | EGLN2ALDH1A1LMNAMEN1CYP1A2 | |
| SCHEMBL26697782 | 0.80 | EGLN2 (0.36) | EGLN2ALDH1A1ENPP1LMNAMAPT | |
| SCHEMBL29309624 | 0.80 | ERBB2 (0.49) | — | |
| SCHEMBL26697667 | 0.78 | CHRM4 (0.39) | ENPP1LMNA | |
| SCHEMBL5952099 | 0.71 | ALDH1A1 (0.62) | ALDH1A1LMNAMEN1MAPTKMT2A | |
| SCHEMBL29936085 | 0.68 | EGLN2 (0.38) | EGLN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL26697752 | 0.68 | EGLN2 (0.38) | EGLN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL26697663 | 0.67 | STK39 (0.45) | PGRARALDH1A1MEN1KMT2A | |
| SCHEMBL27093496 | 0.66 | KDM4E (0.36) | EGLN2ALDH1A1LMNAMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118459485-A | Amino-substituted heterocycles for the treatment of cancers with EGFR mutations | 纽威伦特公司 | 2024-08-09 | — | — | CN | disclosed |