Sugi Predict

Sugi Predict / Targets / STK39

STK39

STE20/SPS1-related proline-alanine-rich protein kinase · Q9UEW8 · STK39 on Sugi Atlas →

3,086 patent compounds predicted against STK39, 2,131 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2167442 SCHEMBL2167442 0.64 15/20
SCHEMBL2166819 SCHEMBL2166819 0.72 13/20
SCHEMBL2168030 SCHEMBL2168030 0.72 13/20
SCHEMBL2168339 SCHEMBL2168339 0.58 13/20
SCHEMBL5655299 SCHEMBL5655299 0.58 12/20
SCHEMBL649911 SCHEMBL649911 0.70 11/20
SCHEMBL5658654 SCHEMBL5658654 0.60 11/20
3,3',4',5-Tetrachlorosalicylanilide 3,3',4',5-Tetrachlorosalicylanilide (SCHEMBL168748) 0.71 10/20
SCHEMBL8672680 SCHEMBL8672680 0.65 10/20
SCHEMBL5658052 SCHEMBL5658052 0.63 10/20
SCHEMBL9136004 SCHEMBL9136004 0.57 9/20
SCHEMBL4355989 SCHEMBL4355989 0.67 8/20
SCHEMBL6451577 SCHEMBL6451577 0.62 8/20
SCHEMBL8657631 SCHEMBL8657631 0.54 8/20
SCHEMBL3713890 SCHEMBL3713890 0.49 8/20
SCHEMBL2167171 SCHEMBL2167171 0.57 7/20
SCHEMBL4364343 SCHEMBL4364343 0.52 7/20
SCHEMBL4346853 SCHEMBL4346853 0.51 7/20
Rafoxanide Rafoxanide (SCHEMBL8734643) 0.44 7/20
SCHEMBL684755 SCHEMBL684755 0.44 7/20

Clinical trials — most relevant to STK39 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Salt Loading and Thiazide Intervention Study PHASE4COMPLETED
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer PHASE2COMPLETED
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer nanUNKNOWN
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases nanNOT_YET_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia nanUNKNOWN
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis nanNOT_YET_RECRUITING
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children nanCOMPLETED
Genetic-specific Effects of Fructose on Liver Lipogenesis nanCOMPLETED
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Consequences of Mutations in the SPG7 Gene at the Heterozygous State nanCOMPLETED
Quantification of GADD34 Expression in RA nanCOMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers nanCOMPLETED
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity nanCOMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy nanRECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Pharmacogenetics of Metformin Action in PCOS nanCOMPLETED
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease nanUNKNOWN
Genes-in-Action - Hepcidin Regulation of Iron Supplementation nanCOMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a STK39 binder may also engage these)

ProteinNameSimilarity
O88506 — 1.000 O88506 →
Q9Z1W9 — 1.000 Q9Z1W9 →
Q863I2 — 0.996 Q863I2 →
Q6P9R2 — 0.994 Q6P9R2 →
A0A8I5ZNK2 — 0.993 A0A8I5ZNK2 →
Q5R495 — 0.987 Q5R495 →
OXSR1 Serine/threonine-protein kinase OSR1 0.986 landscape →
MAPKAPK2 MAP kinase-activated protein kinase 2 0.969 landscape →
PRKD1 Serine/threonine-protein kinase D1 0.968 landscape →
Q62696 — 0.966 Q62696 →
Q5XIS9 — 0.964 Q5XIS9 →
O55047 — 0.963 O55047 →
Q811D0 — 0.962 Q811D0 →
Q5PYH5 — 0.962 Q5PYH5 →
Q9WTQ1 — 0.960 Q9WTQ1 →
PRKD2 Serine/threonine-protein kinase D2 0.960 landscape →
Q1ECX4 — 0.960 Q1ECX4 →
Q12959 — 0.960 Q12959 →
A0A8C0TYJ0 — 0.958 A0A8C0TYJ0 →
A2AWA9 — 0.958 A2AWA9 →
Q2KJ46 — 0.958 Q2KJ46 →
Q8BZ03 — 0.958 Q8BZ03 →
Q9Y3P9 — 0.957 Q9Y3P9 →
D2XV59 — 0.957 D2XV59 →
PSMD3 26S proteasome non-ATPase regulatory subunit 3 0.957 landscape →
Q9ERG2 — 0.957 Q9ERG2 →
Q08CW1 — 0.956 Q08CW1 →
Q5RAN1 — 0.956 Q5RAN1 →
Q08E27 — 0.956 Q08E27 →
Q68FK8 — 0.956 Q68FK8 →