Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31055396 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL4075783 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL31055452 | 0.84 | HPGD (0.59) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL12760708 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL13702278 | 0.80 | HPGD (0.47) | SMN1; SMN2LMNANPC1RAB9AHPGD | |
| SCHEMBL17887994 | 0.79 | SMN1; SMN2 (0.77) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL18193848 | 0.79 | NPC1 (0.67) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL10099572 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL25031639 | 0.77 | ALDH1A1 (0.51) | LMNANPC1RAB9APKMGAA | |
| SCHEMBL31055441 | 0.77 | TSHR (0.59) | SMN1; SMN2LMNANPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118480001-A | C-Kit (V559D)/PDGFR beta double-target allosteric inhibitor and preparation method, pharmaceutical composition and application thereof | 贵州省天然产物研究中心 | 2024-08-13 | — | — | CN | disclosed |