Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 13/20 | 0.69 |
| ▸ | SHMT2 | P34897 | 12/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057961 | 0.91 | SHMT1 (0.68) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL31057912 | 0.90 | SHMT1 (0.74) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL31057774 | 0.89 | SHMT2 (0.56) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL31057869 | 0.89 | SHMT2 (0.56) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL31057911 | 0.89 | KDM4E (0.55) | SHMT1SHMT2KDM4EALDH1A1HPGD | |
| SCHEMBL31057793 | 0.88 | SHMT2 (0.55) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL31057785 | 0.87 | SHMT1 (0.51) | SHMT1SHMT2KDM4EALDH1A1HPGD | |
| SCHEMBL31057781 | 0.82 | SHMT2 (0.62) | SHMT1SHMT2EGLN1KDM4EALDH1A1 | |
| SCHEMBL20255575 | 0.82 | SHMT1 (1.00) | SHMT1SHMT2EGLN1 | |
| SCHEMBL31057898 | 0.82 | SHMT2 (0.54) | SHMT1SHMT2EGLN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |