Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 5/20 | 0.45 |
| ▸ | SHMT1 | P34896 | 4/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057952 | 0.85 | SHMT2 (0.52) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057931 | 0.85 | SHMT2 (0.47) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057737 | 0.84 | SHMT2 (0.52) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057885 | 0.84 | SHMT2 (0.47) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057941 | 0.82 | SHMT2 (0.47) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057813 | 0.73 | MAPT (0.42) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL20255896 | 0.73 | KDM4E (0.76) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057890 | 0.72 | SHMT2 (0.56) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31057918 | 0.72 | SHMT2 (0.58) | SHMT2SHMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL31058015 | 0.71 | SHMT2 (0.57) | SHMT2SHMT1EGLN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |