Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 5/20 | 0.52 |
| ▸ | SHMT1 | P34896 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057737 | 0.92 | SHMT2 (0.52) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057941 | 0.87 | SHMT2 (0.47) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057931 | 0.87 | SHMT2 (0.47) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057885 | 0.86 | SHMT2 (0.47) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057926 | 0.85 | SHMT2 (0.45) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057813 | 0.81 | MAPT (0.42) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL20255896 | 0.79 | KDM4E (0.76) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057890 | 0.78 | SHMT2 (0.56) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057855 | 0.77 | SHMT2 (0.55) | SHMT2SHMT1ALDH1A1KDM4EHPGD | |
| SCHEMBL31057781 | 0.77 | SHMT2 (0.62) | SHMT2SHMT1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |