SCHEMBL31060422

SCHEMBL31060422

O=C1NN(c2ccc(Cl)c(Cl)c2)C(=O)C1=Cc1cccc(OCc2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SRC P12931 2/20 1.00
ABL1 P00519 1/20 1.00
EGFR P00533 2/20 0.69
NR1H4 Q96RI1 5/20 0.68
ARHGEF12 Q9NZN5 1/20 0.68
DYRK1A Q13627 7/20 0.60
MEN1 O00255 1/20 0.60
ALDH1A1 P00352 1/20 0.60
MAPT P10636 1/20 0.60
HPGD P15428 1/20 0.60
ALOX12 P18054 1/20 0.60
RECQL P46063 1/20 0.60
KMT2A Q03164 1/20 0.60
MCL1 Q07820 1/20 0.60
GSK3B P49841 1/20 0.59
JAK2 O60674 1/20 0.55
ZAP70 P43403 1/20 0.55
POLB P06746 1/20 0.53
GAA P10253 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15936914 0.81 NR1H4 (1.00) SRCABL1EGFRNR1H4ARHGEF12
SCHEMBL25138474 0.81 NR1H4 (1.00) SRCABL1EGFRNR1H4ARHGEF12
SCHEMBL15936931 0.77 EGFR (0.72) SRCABL1EGFRNR1H4ARHGEF12
SCHEMBL12768594 0.75 HPGD (1.00) SRCABL1EGFRDYRK1AMEN1
SCHEMBL3760714 0.74 DYRK1A (1.00) SRCABL1EGFRDYRK1AMEN1
SCHEMBL3760715 0.74 DYRK1A (1.00) SRCABL1EGFRDYRK1AMEN1
SCHEMBL3760719 0.74 DYRK1A (1.00) SRCABL1EGFRDYRK1AMEN1
SCHEMBL19685492 0.74 NR1H4 (0.78) SRCABL1EGFRNR1H4ARHGEF12
SCHEMBL13044232 0.73 MEN1 (0.76) SRCABL1NR1H4ARHGEF12MEN1
SCHEMBL13848508 0.71 SIRT2 (0.75) SRCABL1NR1H4ARHGEF12MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed