Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.78 |
| ▸ | ARHGEF12 | Q9NZN5 | 1/20 | 0.78 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15936914 | 0.88 | NR1H4 (1.00) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL25138474 | 0.88 | NR1H4 (1.00) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL31060422 | 0.74 | SRC (1.00) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL2398010 | 0.71 | KMT2A (0.74) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL196142 | 0.71 | KMT2A (0.74) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL12267471 | 0.71 | KMT2A (0.74) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL17618257 | 0.69 | NR1H4 (0.61) | NR1H4ARHGEF12SRCABL1POLB | |
| SCHEMBL12516122 | 0.68 | MAOB (1.00) | NR1H4ARHGEF12MAOAMAOBALDH1A1 | |
| SCHEMBL15936931 | 0.67 | EGFR (0.72) | NR1H4ARHGEF12SRCABL1EGFR | |
| SCHEMBL5735042 | 0.66 | ABL1 (0.61) | NR1H4ARHGEF12SRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951024-B2 | Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170349553-A1 | SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | UNIVERSITY OF CINCINNATI | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349553-A1 | SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | ARHGEF1, ARHGEF2, ARHGDIB | NR1H4 1982/4885ARHGEF12 6/4885SRC 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.