Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitoxantrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 2/20 | 0.86 |
| ▸ | MEN1 | O00255 | 4/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.86 |
| ▸ | BLM | P54132 | 3/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.86 |
| ▸ | NSD2 | O96028 | 3/20 | 0.86 |
| ▸ | NPC1 | O15118 | 3/20 | 0.86 |
| ▸ | RAB9A | P51151 | 3/20 | 0.86 |
| ▸ | USP2 | O75604 | 2/20 | 0.86 |
| ▸ | TP53 | P04637 | 2/20 | 0.86 |
| ▸ | RECQL | P46063 | 2/20 | 0.86 |
| ▸ | MTOR | P42345 | 2/20 | 0.86 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.86 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.86 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.86 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitoxantrone SCHEMBL31237733 | 1.00 | MEN1 (0.86) | MEN1KMT2ABLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL119801 | 1.00 | MEN1 (0.86) | MEN1KMT2ABLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL21874585 | 0.93 | MEN1 (0.89) | MEN1KMT2ABLMLMNAMAPK1 | |
| SCHEMBL11391594 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL20214110 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| SCHEMBL11041207 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL3000 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| SCHEMBL11517949 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| SCHEMBL11036806 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL29720597 | 0.93 | MEN1 (1.00) | MEN1KMT2ABLMLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |