Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31062479 | 0.84 | HSP90AB1 (0.38) | KDM4ECHRM3MTNR1AMTNR1B | |
| SCHEMBL31062441 | 0.82 | SUCNR1 (0.44) | KDM4ECFDSMN1; SMN2 | |
| SCHEMBL31062262 | 0.82 | CHRM3 (0.41) | KDM4ECHRM3CFDSLC6A3 | |
| SCHEMBL506923 | 0.77 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2 | |
| SCHEMBL2972991 | 0.75 | MEP1B (0.48) | KDM4ESMN1; SMN2 | |
| SCHEMBL13726819 | 0.75 | NR4A2 (0.43) | PDK2CD274 | |
| SCHEMBL30609912 | 0.75 | NR4A2 (0.43) | PDK2CD274 | |
| SCHEMBL13824067 | 0.75 | SLC6A3 (0.56) | KDM4ESMN1; SMN2PDK2DHODHSLC6A4 | |
| SCHEMBL18261999 | 0.74 | KDM4E (0.43) | KDM4ECFDSMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL31284578 | 0.74 | KDM4E (0.43) | KDM4ECFDSMN1; SMN2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024168004-A1 | BIARYL AMIDE-CONTAINING AGONISTS OF OREXIN RECEPTOR TYPE 2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-08-15 | — | — | WO | disclosed |