Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | ATP4A | P20648 | 4/20 | 0.43 |
| ▸ | ATP4B | P51164 | 4/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31063713 | 0.89 | LRRK2 (0.55) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL31063720 | 0.86 | INSR (0.49) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31063730 | 0.86 | NPC1 (0.57) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31063725 | 0.83 | APP (0.65) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL31063734 | 0.83 | ATP4A (0.60) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL31063740 | 0.81 | ATP4A (0.58) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL31063864 | 0.79 | NPC1 (0.55) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31063762 | 0.79 | ATP4A (0.49) | MAPTNPC1RAB9ASMN1; SMN2APP | |
| SCHEMBL31063606 | 0.79 | KAT8 (0.52) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31063751 | 0.78 | NPC1 (0.54) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024200263-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS α-SYNUCLEIN BINDING COMPOUNDS | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2024-10-03 | — | — | WO | disclosed |
| EP-4438597-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS A-SYNUCLEIN BINDING COMPOUNDS | Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) | 2024-10-02 | — | — | EP | disclosed |