SCHEMBL31064183

SCHEMBL31064183

CC(C(=O)O)c1ccccc1C#C[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
MMP2 P08253 2/20 0.39
MMP9 P14780 2/20 0.39
MMP8 P22894 2/20 0.39
MMP12 P39900 2/20 0.39
MMP13 P45452 2/20 0.39
MMP14 P50281 2/20 0.39
MMP16 P51512 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12478214 1.00 MAPT (0.41) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL15502435 0.86 CXCL8 (0.40) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL14576568 0.83 KMT2A (0.39) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL15502329 0.80 TSHR (0.39) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL28728194 0.80 KDM4E (0.42) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL4095370 0.79 CYP1A2 (0.41) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL1679444 0.79 PPARA (0.36) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL15568562 0.76 CXCL8 (0.46) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL31561697 0.76 L3MBTL1 (0.45) MAPTKDM4EALDH1A1CYP3A4HPGD
SCHEMBL7050570 0.76 L3MBTL1 (0.45) MAPTKDM4EALDH1A1CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118576593-A Inhibitor for SARS-CoV-2 spike glycoprotein and its use 香港大学深圳研究院 2024-09-03 CN disclosed