Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567841 | 1.00 | FEN1 (0.50) | FEN1PARP1KDM4ECA12CA9 | |
| SCHEMBL24575981 | 0.81 | FEN1 (0.47) | FEN1PARP1KDM4ECA12CA9 | |
| SCHEMBL9128769 | 0.76 | FEN1 (0.50) | FEN1PARP1KDM4ECA12CA9 | |
| SCHEMBL7030237 | 0.76 | DAO (0.41) | PARP1KDM4ECA12CA9DAO | |
| SCHEMBL6645136 | 0.76 | KDM4E (0.48) | PARP1KDM4ECA12CA9TYMP | |
| SCHEMBL3125353 | 0.76 | PARP1 (0.49) | PARP1KDM4ECA12CA9DAO | |
| SCHEMBL16529364 | 0.76 | KDM4E (0.48) | PARP1KDM4ECA12CA9GRIN2D | |
| SCHEMBL12832866 | 0.76 | KDM4E (0.48) | PARP1KDM4ECA12CA9GRIN2D | |
| SCHEMBL4515077 | 0.76 | PARP1 (0.48) | PARP1KDM4ECA12CA9GRIN2D | |
| SCHEMBL8144559 | 0.76 | IMPDH2 (0.50) | PARP1KDM4ECA12CA9DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358955-B2 | 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP inhibitors and the use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2022-06-14 | — | — | US | claimed |
| US-20250270212-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS INC (US) | 2025-08-28 | — | — | US | disclosed |
| EP-4416151-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | Padarn Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| US-20230399316-A1 | CRYSTAL FORMS OF 5-FLUORO-1-(4-FLUORO-3-(4-(PYRIMIDIN-2-YL)PIPERAZINE-1-CARBONYL)BENZYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND PREPARATION THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2023-12-14 | — | — | US | disclosed |
| US-20230399316-A1 | CRYSTAL FORMS OF 5-FLUORO-1-(4-FLUORO-3-(4-(PYRIMIDIN-2-YL)PIPERAZINE-1-CARBONYL)BENZYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND PREPARATION THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2023-12-14 | — | — | US | disclosed |
| WO-2023064164-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023064164-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| US-11358955-B2 | 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP inhibitors and the use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2022-06-14 | — | — | US | disclosed |
| WO-2022100577-A1 | CRYSTAL FORMS OF 5-FLUORO-1-(4-FLUORO-3-(4-(PYRIMIDIN-2-YL)PIPERAZINE-1-CARBONYL)BENZYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND PREPARATION THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-05-19 | — | — | WO | disclosed |
| EP-3438096-B1 | MANUFACTURING PROCESS FOR 1-(ARYLMETHYL) QUINAZOLINE-2,4 (1H, 3H)-DIONE | IMPACT THERAPEUTICS INC (CN) | 2020-12-02 | — | — | EP | disclosed |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040242566-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004087053-A9 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX INC (US) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| EP-0878468-B1 | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL CO (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-0775697-B1 | Process for producing 1-substituted tetrahydroquinazolindionen | SUMITOMO CHEMICAL CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5994542-A | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-11-30 | — | — | US | disclosed |
| EP-0878468-A1 | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5756738-A | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0775697-A1 | Process for producing 1-substituted tetrahydroquinazolindionen | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-05-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242566-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP3, DPP4 | FEN1 962/4885PARP1 2025/4885KDM4E 2254/4885 |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | FEN1 1883/4885PARP1 1840/4885KDM4E 2122/4885 |
| US-20230399316-A1 | CRYSTAL FORMS OF 5-FLUORO-1-(4-FLUORO-3-(4-(PYRIMIDIN-2-YL)PIPERAZINE-1-CARBONYL)BENZYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND PREPARATION THEREOF | NT5C, DCUN1D5, PYM1 | FEN1 799/4885PARP1 133/4885KDM4E 1122/4885 |
| US-20250270212-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | WEE1, WEE2, PARP1 | FEN1 55/4885PARP1 3/4885KDM4E 2398/4885 |
| US-11358955-B2 | 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP inhibitors and the use thereof | PARP1, PARP11, PARP3 | FEN1 182/4885PARP1 1/4885KDM4E 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.