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Sugi Predict / Targets / NT5C

NT5C

5'(3')-deoxyribonucleotidase, cytosolic type · Q8TCD5 · NT5C on Sugi Atlas →

19 patent compounds predicted against NT5C, 17 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29941559 SCHEMBL29941559 0.55 1/20
SCHEMBL3077768 SCHEMBL3077768 0.42 1/20
SCHEMBL3077770 SCHEMBL3077770 0.42 1/20
SCHEMBL3085098 SCHEMBL3085098 0.42 1/20
SCHEMBL3085099 SCHEMBL3085099 0.42 1/20
SCHEMBL16871723 SCHEMBL16871723 0.41 1/20
SCHEMBL8997876 SCHEMBL8997876 0.41 1/20
SCHEMBL2915110 SCHEMBL2915110 0.40 1/20
SCHEMBL2915114 SCHEMBL2915114 0.40 1/20
SCHEMBL2915121 SCHEMBL2915121 0.40 1/20
SCHEMBL2915125 SCHEMBL2915125 0.40 1/20
SCHEMBL2919190 SCHEMBL2919190 0.40 1/20
SCHEMBL2919193 SCHEMBL2919193 0.40 1/20
SCHEMBL2919240 SCHEMBL2919240 0.40 1/20
SCHEMBL2919241 SCHEMBL2919241 0.40 1/20
SCHEMBL2921132 SCHEMBL2921132 0.40 1/20
SCHEMBL2921134 SCHEMBL2921134 0.40 1/20

Clinical trials — most relevant to NT5C by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study PHASE3COMPLETED
Chronic Sildenafil Treatment in Heart Failure PHASE3COMPLETED
Medication and Counseling for Controlled Drinking (Project SMART) PHASE3COMPLETED
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema PHASE2COMPLETED
PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction PHASE2COMPLETED
Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study) PHASE1/PHASE2RECRUITING
Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations PHASE2SUSPENDED
Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer PHASE2RECRUITING
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Nucleoside Therapy in Patients With Telomere Biology Disorders PHASE1RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of MNS075 (Intranasal Morphine) PHASE1COMPLETED
PRO#0118: Decitabine Plus Mini Flu-Bu PHASE1COMPLETED
Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies nanUNKNOWN
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Computer-Facilitated 5A's for Smoking Cessation in Primary Care nanCOMPLETED
C-Type Natriuretic Peptide and Achondroplasia nanCOMPLETED
DNA Adductomics for Colorectal Cancer Investigation nanUNKNOWN
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED
Sickle Cell Disease (SCD) Bone Pain Study nanACTIVE_NOT_RECRUITING
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43 nanUNKNOWN
Genetic Epidemiology of Coronary Heart Disease nanCOMPLETED
Evaluation of the Effectiveness of 5A-5R Counselling Services for Tobacco Cessation nanENROLLING_BY_INVITATION
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
A Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA nanUNKNOWN
CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD nanENROLLING_BY_INVITATION
Using the Epitranscriptome to Diagnose and Treat Gliomas nanRECRUITING
Biomedical Investigations for Optimized Diagnosis and Monitoring of Severe Acute Malnutrition (SAM): Elucidating the Heterogeneous Diagnosis of SAM by Current Anthropometric Criteria and Moving Beyond nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NT5C binder may also engage these)

ProteinNameSimilarity
Q9JM14 — 0.978 Q9JM14 →
NT5M 5'(3')-deoxyribonucleotidase, mitochondrial 0.965 landscape →
Q8VCE6 — 0.960 Q8VCE6 →
PNKP Bifunctional polynucleotide phosphatase/kinase 0.960 landscape →
HDHD5 Haloacid dehalogenase-like hydrolase domain-containing 5 0.953 landscape →
RHOT2 Mitochondrial Rho GTPase 2 0.952 landscape →
Q148G5 — 0.952 Q148G5 →
Q7TSA0 — 0.952 Q7TSA0 →
ALG1 Chitobiosyldiphosphodolichol beta-mannosyltransferase 0.952 landscape →
LPCAT1 Lysophosphatidylcholine acyltransferase 1 0.952 landscape →
O43272 — 0.951 O43272 →
Q5E9M9 — 0.951 Q5E9M9 →
Q5R7A2 — 0.951 Q5R7A2 →
Q86TX2 — 0.951 Q86TX2 →
Q8JZN7 — 0.951 Q8JZN7 →
A5GFZ6 — 0.951 A5GFZ6 →
Q921Q3 — 0.950 Q921Q3 →
Q9D967 — 0.950 Q9D967 →
Q9JLV6 — 0.950 Q9JLV6 →
Q6NS21 — 0.949 Q6NS21 →
O97583 — 0.949 O97583 →
Q66JK4 — 0.948 Q66JK4 →
Q864R5 — 0.947 Q864R5 →
A1A4L8 — 0.947 A1A4L8 →
D3ZDK7 — 0.946 D3ZDK7 →
Q86V88 — 0.946 Q86V88 →
Q5NVK5 — 0.946 Q5NVK5 →
Q4V9J0 — 0.946 Q4V9J0 →
Q3KQV9 — 0.946 Q3KQV9 →
Q60714 — 0.946 Q60714 →