Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 1.00 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.65 |
| ▸ | CDK1 | P06493 | 2/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.65 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.65 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997190 | 1.00 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3009852 | 0.85 | RIPK1 (0.74) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2995238 | 0.84 | RIPK1 (0.73) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3006162 | 0.84 | RIPK1 (0.73) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3004549 | 0.82 | RIPK1 (0.69) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL28277239 | 0.81 | RIPK1 (0.68) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL29460546 | 0.79 | RIPK1 (0.65) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL30694450 | 0.78 | RIPK1 (0.64) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL29625211 | 0.78 | RIPK1 (0.64) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL31064968 | 0.78 | RIPK1 (0.63) | RIPK1CCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344359-A | RIPK1 kinase targeted inhibitor and application thereof | 中国药科大学 | 2024-07-16 | — | — | CN | disclosed |