Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009852 | 0.79 | RIPK1 (0.74) | RIPK1GSK3BCDK5CDK5R1DAO | |
| SCHEMBL31064965 | 0.78 | RIPK1 (1.00) | RIPK1GSK3BCDK5CDK5R1DAO | |
| SCHEMBL2997190 | 0.78 | RIPK1 (1.00) | RIPK1GSK3BCDK5CDK5R1DAO | |
| SCHEMBL7151357 | 0.77 | RIPK1 (0.57) | RIPK1DAOCCNB2CDK1CCNB1 | |
| SCHEMBL31065003 | 0.77 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL14115574 | 0.77 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL18741322 | 0.76 | RIPK1 (1.00) | RIPK1GSK3BCDK5CDK5R1CCNB2 | |
| SCHEMBL1777660 | 0.75 | IGF1R (0.67) | RIPK1GSK3BCDK5CCNB2CDK1 | |
| SCHEMBL29460546 | 0.73 | RIPK1 (0.65) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL5960512 | 0.73 | ESR2 (0.61) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344359-A | RIPK1 kinase targeted inhibitor and application thereof | 中国药科大学 | 2024-07-16 | — | — | CN | disclosed |