Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16416975 | 0.81 | AXL (0.50) | MAPK1BRD4ARMAPTALDH1A1 | |
| SCHEMBL16417014 | 0.81 | MAPK1 (0.54) | RIPK1MAPK1BRD4ALDH1A1POLB | |
| SCHEMBL14735035 | 0.81 | BRD4 (0.53) | MAPK1BRD4MAPTALDH1A1POLB | |
| SCHEMBL16417000 | 0.77 | BRD4 (0.61) | MAPK1BRD4MAPTALDH1A1POLB | |
| SCHEMBL16417052 | 0.77 | BRD4 (0.50) | BRD4MAPTALDH1A1HSD17B10 | |
| SCHEMBL23110560 | 0.77 | BRD4 (0.50) | RIPK1MAPK1BRD4CDK2 | |
| SCHEMBL29802407 | 0.75 | BRD4 (0.48) | BRD4ALDH1A1NPC1RAB9A | |
| SCHEMBL5739133 | 0.75 | BRD4 (0.48) | BRD4ALDH1A1NPC1RAB9A | |
| SCHEMBL14896431 | 0.74 | FGFR1 (0.54) | RIPK1MAPK1ESR1ESR2AR | |
| SCHEMBL12027878 | 0.71 | APP (0.52) | RIPK1MAPK1MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344359-A | RIPK1 kinase targeted inhibitor and application thereof | 中国药科大学 | 2024-07-16 | — | — | CN | disclosed |