Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116637 | 0.90 | TBK1 (0.38) | PIK3CAPIK3CDPIK3R2PIK3CGALDH1A1 | |
| SCHEMBL3110150 | 0.88 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL3113004 | 0.88 | PIK3CA (0.39) | PIK3CAHRH1HRH4PIK3CDPIK3CG | |
| SCHEMBL3099239 | 0.87 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3R2PIK3CGMTOR | |
| SCHEMBL114963 | 0.87 | PIK3CA (0.46) | PIK3CAMTORPFKFB3 | |
| SCHEMBL3111597 | 0.87 | PIK3CA (0.43) | PIK3CAHRH1HRH4PIK3CDPIK3CG | |
| SCHEMBL114787 | 0.85 | FAAH (0.41) | PIK3CAHRH1HRH4PIK3CDPIK3CG | |
| SCHEMBL3114997 | 0.82 | PIK3CA (0.34) | PIK3CAPIK3CDPIK3R2PIK3CG | |
| SCHEMBL3114966 | 0.81 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CGPFKFB3 | |
| SCHEMBL3111200 | 0.79 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CGMTORPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8772480-B2 | Inhibitors of PI3 kinase and/or mTOR | AMGEN INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130079303-A1 | Inhibitors of PI3 Kinase and/or mTOR | AMGEN INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | AMGEN INC. (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | MTOR, PIK3CA, PIK3CD | PIK3CA 2/4885HRH1 3323/4885HRH4 3774/4885 |
| US-20130079303-A1 | Inhibitors of PI3 Kinase and/or mTOR | MTOR, PIK3CA, PIK3CD | PIK3CA 2/4885HRH1 3323/4885HRH4 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.