Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.44 |
| ▸ | NQO2 | P16083 | 7/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BRD1 | O95696 | 2/20 | 0.37 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29131019 | 0.77 | CYP19A1 (0.44) | CYP19A1NQO2ADORA1MAPTL3MBTL1 | |
| SCHEMBL98218 | 0.76 | CYP19A1 (0.54) | CYP19A1NQO2ADORA1BRPF1BRD9 | |
| SCHEMBL21831553 | 0.76 | CDK4 (0.38) | CYP19A1NQO2MAPT | |
| SCHEMBL3099860 | 0.76 | BRPF1 (0.40) | BRPF1BRD9CA12BRD4CA9 | |
| SCHEMBL3110339 | 0.72 | ALDH1A1 (0.40) | CYP19A1NQO2ADORA1BRPF1BRD9 | |
| SCHEMBL3113411 | 0.71 | ALDH1A1 (0.55) | CYP19A1NQO2ADORA1L3MBTL1RAB9A | |
| SCHEMBL23832583 | 0.71 | CSNK2A2 (0.42) | CYP19A1NQO2ADORA1BRD4ALDH1A1 | |
| SCHEMBL17576626 | 0.71 | BRPF1 (0.52) | ADORA1BRPF1BRD9CA12BRD4 | |
| SCHEMBL30665881 | 0.71 | BRPF1 (0.52) | ADORA1BRPF1BRD9CA12BRD4 | |
| SCHEMBL11274030 | 0.70 | BRPF1 (0.50) | CYP19A1NQO2BRPF1BRD9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256124-A1 | Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials | GLAXO GROUP LIMITED (GB) | 2010-10-07 | — | — | US | disclosed |
| EP-2029612-A1 | SUBSTITUTED 1-METHYL-1H-QUINOLIN-2-ONES AND 1-METHYL-1H-1,5-NAPHTHYRIDIN-2-ONES AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008006648-A1 | SUBSTITUTED 1-METHYL-1H-QUINOLIN-2-ONES AND 1-METHYL-1H-1,5-NAPHTHYRIDIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256124-A1 | Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials | TOP1, TOP2A, NDC1 | CYP19A1 2698/4885NQO2 11/4885ADORA1 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.