Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.59 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.59 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CPS1 | P31327 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849764 | 0.86 | MAOB (0.61) | MAPK14MAOBRARARARBMAOA | |
| SCHEMBL5469298 | 0.84 | PARP10 (0.59) | PARP10PARP14PARP15DGAT1GPR119 | |
| SCHEMBL31069762 | 0.84 | PARP10 (0.59) | PARP10PARP14PARP15DGAT1GPR119 | |
| SCHEMBL12116990 | 0.83 | CHEK1 (0.50) | CHEK1CHEK2MAOB | |
| SCHEMBL3079256 | 0.83 | PARP10 (0.58) | PARP10PARP14PARP15DGAT1GPR119 | |
| SCHEMBL22286220 | 0.82 | MAOB (0.44) | PARP10PARP14PARP15MAPK14MAOB | |
| SCHEMBL26028477 | 0.82 | PARP10 (0.54) | PARP10PARP14PARP15DGAT1GPR119 | |
| Hydrochloric Acid SCHEMBL30779145 | 0.81 | PARP10 (0.59) | PARP10PARP14PARP15DGAT1GPR119 | |
| SCHEMBL72082 | 0.80 | CPS1 (0.61) | PARP10PARP14PARP15DGAT1CPS1 | |
| SCHEMBL10468411 | 0.80 | CHEK1 (0.50) | PARP10CHEK1CHEK2MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382457-A1 | BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS | NOVARTIS PHARMA AG (CH) | 2024-11-21 | — | — | US | disclosed |
| US-12083101-B2 | Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors | NOVARTIS AG (CH) | 2024-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12083101-B2 | Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors | YAP1, TEAD3, TEAD2 | PARP10 653/4885PARP14 1322/4885PARP15 444/4885 |
| US-20240382457-A1 | BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS | YAP1, TEAD3, TEAD2 | PARP10 653/4885PARP14 1322/4885PARP15 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.