Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.56 |
| ▸ | CA2 | P00918 | 9/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.50 |
| ▸ | CA9 | Q16790 | 8/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352176 | 0.85 | PTGS2 (0.69) | CA1CA2PTGS2CA9PTGS1 | |
| SCHEMBL14292307 | 0.83 | CA1 (0.50) | CA1CA2PTGS2CA9CA12 | |
| SCHEMBL3102280 | 0.79 | PTGS2 (0.63) | CA1CA2PTGS2CA9PTGS1 | |
| SCHEMBL3103871 | 0.75 | CA1 (0.50) | CA1CA2PTGS2CA9CA12 | |
| Benzenesulfonamide SCHEMBL29119602 | 0.73 | CA2 (0.86) | CA1CA2CA9CA12CA4 | |
| SCHEMBL6343299 | 0.73 | PTGS2 (0.72) | CA1CA2PTGS2CA9PTGS1 | |
| SCHEMBL3240000 | 0.73 | CA9 (0.52) | CA1CA2PTGS2CA9CA12 | |
| SCHEMBL5698738 | 0.72 | PTGS2 (0.65) | CA1CA2PTGS2CA9CA12 | |
| SCHEMBL6345389 | 0.72 | CA9 (0.70) | CA1CA2PTGS2CA9PTGS1 | |
| SCHEMBL3108950 | 0.71 | CA1 (0.51) | CA1CA2PTGS2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | AGOURON PHARMACEUTICALS, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256357-A1 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | CA2, CA7, CA9 | CA1 7/4885CA2 1/4885PTGS2 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.