Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24709631 | 0.86 | HRH3 (0.47) | SMN1; SMN2L3MBTL1HRH3LMNAPOLB | |
| SCHEMBL31075110 | 0.84 | HRH3 (0.48) | SMN1; SMN2HRH3POLBHTTALDH1A1 | |
| SCHEMBL1052899 | 0.84 | HRH3 (0.48) | SMN1; SMN2HRH3LMNAHTTALDH1A1 | |
| SCHEMBL19931764 | 0.83 | HRH3 (0.49) | SMN1; SMN2HRH3LMNAHTTALDH1A1 | |
| SCHEMBL7454861 | 0.83 | HRH3 (0.49) | SMN1; SMN2HRH3LMNAHTTALDH1A1 | |
| SCHEMBL9281583 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2HRH3POLBHTTALDH1A1 | |
| SCHEMBL8829186 | 0.81 | HRH3 (0.48) | SMN1; SMN2HRH3LMNAHTTALDH1A1 | |
| SCHEMBL18915030 | 0.81 | HRH3 (0.48) | SMN1; SMN2HRH3LMNAHTTALDH1A1 | |
| SCHEMBL13965741 | 0.81 | HRH3 (0.48) | SMN1; SMN2HRH3LMNAALDH1A1KMT2A | |
| SCHEMBL2799202 | 0.81 | HRH3 (0.50) | SMN1; SMN2HRH3HTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673214-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2026-01-07 | — | — | EP | disclosed |
| WO-2024180206-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-09-06 | — | — | WO | disclosed |