Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31075230 | 0.85 | POLB (0.44) | GRM2NPC1RAB9AKDM4ERXFP1 | |
| SCHEMBL31075335 | 0.84 | HSD17B10 (0.48) | KLKB1BTKOPRM1OPRK1 | |
| SCHEMBL3101067 | 0.81 | KMT2A (0.51) | GRM2NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL18795048 | 0.81 | GRM2 (0.55) | GRM2NPC1KLKB1SMN1; SMN2 | |
| SCHEMBL1909166 | 0.80 | GRM2 (0.53) | GRM2NPC1KDM4EKMT2AKLKB1 | |
| SCHEMBL28595790 | 0.79 | ESR1 (0.55) | GRM2NPC1KDM4EKMT2AKLKB1 | |
| SCHEMBL2821953 | 0.79 | LMNA (0.54) | GRM2NPC1RAB9AKLKB1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL31075300 | 0.78 | HSD17B10 (0.43) | CACNA1HKLKB1BTKOPRM1OPRK1 | |
| SCHEMBL19471906 | 0.78 | KLKB1 (0.56) | CACNA1HNPC1RAB9AKDM4ERXFP1 | |
| SCHEMBL554548 | 0.78 | GRM2 (0.51) | GRM2NPC1KDM4EKMT2AKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |