Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18816485 | 0.85 | BTK (0.51) | GRM2KMT2AACACBBTK | |
| SCHEMBL31075155 | 0.85 | P2RY12 (0.45) | GRM2OGAKMT2ABTKPIK3CA | |
| SCHEMBL31075273 | 0.83 | L3MBTL1 (0.46) | POLBBTKALDH1A1LMNA | |
| SCHEMBL12952642 | 0.81 | POLB (0.54) | POLBMAPTOGAPDE4BKMT2A | |
| SCHEMBL31075223 | 0.80 | GRM2 (0.44) | POLBMAPTGRM2KMT2AMEN1 | |
| SCHEMBL23773841 | 0.79 | GRM2 (0.40) | POLBMAPTGRM2ACACBBTK | |
| SCHEMBL29390128 | 0.79 | BTK (0.41) | MAPTPDE4BBTKALDH1A1LMNA | |
| SCHEMBL6984326 | 0.78 | MAPT (0.57) | POLBMAPTOGAPDE4BKMT2A | |
| SCHEMBL1909166 | 0.77 | GRM2 (0.53) | GRM2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL25678417 | 0.77 | MAPT (0.56) | POLBMAPTOGAPDE4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |