Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328314 | 0.74 | NPC1 (0.41) | NOTUMKDM4EPOLBNPSR1NPC1 | |
| SCHEMBL29719717 | 0.72 | NOTUM (0.53) | NOTUMCASP3CYP3A4POLBHSD11B1 | |
| SCHEMBL12071484 | 0.68 | NOTUM (0.50) | NOTUMCASP3CYP3A4POLBLMNA | |
| SCHEMBL31692083 | 0.68 | NOTUM (0.41) | NOTUMESR1CASP3MAPKAPK2KDM4E | |
| SCHEMBL19683347 | 0.68 | NOTUM (0.41) | NOTUMESR1CASP3MAPKAPK2KDM4E | |
| SCHEMBL18856572 | 0.68 | ESR1 (0.43) | NOTUMESR1CASP3CYP3A4MAPKAPK2 | |
| SCHEMBL3030714 | 0.67 | ALDH1A1 (0.50) | NOTUMESR1CYP3A4KDM4EPOLB | |
| SCHEMBL12497363 | 0.66 | NOTUM (0.48) | NOTUMESR1CYP3A4HSD11B1CYP1A2 | |
| SCHEMBL3102519 | 0.66 | NOTUM (0.42) | NOTUMESR1MAPKAPK2KDM4EPOLB | |
| SCHEMBL3094113 | 0.66 | NOTUM (0.39) | NOTUMESR1MAPKAPK2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309580-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20100256156-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256156-A1 | HETEROCYCLIC COMPOUND | GLP1R, GPR119, GCGR | NOTUM 2196/4885ESR1 606/4885CASP3 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.