Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629027 | 0.80 | PTPN2 (0.43) | KMT2APTPN2PTPN1 | |
| SCHEMBL15575400 | 0.78 | BCAT2 (0.46) | KMT2AGSK3BBCAT2 | |
| SCHEMBL1986526 | 0.74 | KMT2A (0.30) | KMT2A | |
| SCHEMBL31613026 | 0.71 | ALDH1A1 (0.39) | KMT2AGSK3BBCAT2PTPN2PTPN1 | |
| SCHEMBL8629005 | 0.70 | KMT2A (0.46) | KMT2A | |
| SCHEMBL8626891 | 0.70 | KMT2A (0.31) | KMT2A | |
| Lithium Ion SCHEMBL29208536 | 0.68 | ALDH1A1 (0.47) | KMT2APTPN1 | |
| Potassium Ion SCHEMBL15876336 | 0.65 | GSK3B (0.55) | KMT2AGSK3B | |
| SCHEMBL10738874 | 0.65 | ALDH1A1 (0.38) | KMT2AGSK3BBCAT2PTPN2PTPN1 | |
| SCHEMBL12213144 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |