Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903024 | 1.00 | NR2E1 (0.64) | NR2E1SIRT1SIRT2HTR1BHPGD | |
| SCHEMBL8592516 | 0.90 | SIRT1 (0.68) | NR2E1SIRT1SIRT2KDM4EHTR5A | |
| Hydrochloric Acid SCHEMBL8595142 | 0.89 | SIRT1 (0.67) | NR2E1SIRT1SIRT2KDM4EHTR5A | |
| SCHEMBL12660565 | 0.88 | NR2E1 (0.60) | NR2E1SIRT1HTR1BHPGDHSD17B10 | |
| SCHEMBL2309545 | 0.88 | NR2E1 (0.60) | NR2E1SIRT1HTR1BHPGDHSD17B10 | |
| SCHEMBL31078875 | 0.88 | NR2E1 (0.60) | NR2E1SIRT1HTR1BHPGDHSD17B10 | |
| SCHEMBL13011893 | 0.85 | NR2E1 (0.57) | NR2E1SIRT1SIRT2HTR1BHPGD | |
| SCHEMBL4728062 | 0.83 | KDM4E (0.63) | NR2E1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL30523188 | 0.83 | KDM4E (0.63) | NR2E1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL30523189 | 0.83 | KDM4E (0.63) | NR2E1HPGDHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121527-B | Tricyclic compounds and uses thereof | 上海辉启生物医药科技有限公司 | 2024-09-06 | — | — | CN | disclosed |