Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078867 | 0.87 | PIK3CA (0.43) | PIK3CDPIK3CBPIK3CACYP3A4ALDH1A1 | |
| SCHEMBL31078627 | 0.82 | TSHR (0.43) | ALDH1A1KDM4EHPGDGAASMN1; SMN2 | |
| SCHEMBL31078796 | 0.81 | HDAC4 (0.31) | IKBKB | |
| SCHEMBL31078876 | 0.70 | KMT2A (0.49) | IKBKBPIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL31078702 | 0.68 | ATM (0.46) | IKBKBPIK3CDPIK3CBPIK3CAALDH1A1 | |
| SCHEMBL3126013 | 0.68 | IKBKB (0.52) | IKBKBPIK3CDPIK3CBPIK3CAALDH1A1 | |
| Lithium Ion SCHEMBL31078410 | 0.67 | HDAC4 (0.31) | — | |
| SCHEMBL7453525 | 0.66 | HSP90AA1 (0.50) | ALDH1A1KDM4EHTTHPGDPRKDC | |
| SCHEMBL18412837 | 0.66 | PIK3CA (0.46) | PIK3CDPIK3CBPIK3CACYP3A4KDM4E | |
| SCHEMBL30798758 | 0.66 | HPGD (0.45) | CYP3A4ALDH1A1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |