Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078867 | 0.83 | PIK3CA (0.43) | TSHRALDH1A1SMN1; SMN2ALOX15GAA | |
| SCHEMBL31078810 | 0.83 | PIN1 (0.33) | TSHRALDH1A1SMN1; SMN2MAPTALOX15 | |
| SCHEMBL31078495 | 0.82 | IKBKB (0.42) | TSHRALDH1A1SMN1; SMN2ALOX15GAA | |
| SCHEMBL18394738 | 0.81 | ALDH1A1 (0.45) | TSHRALDH1A1SMN1; SMN2MAPTALOX15 | |
| SCHEMBL31078892 | 0.75 | POLB (0.44) | TSHRALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL31078648 | 0.72 | TSHR (0.44) | TSHRALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL27029191 | 0.70 | PRKDC (0.44) | ALDH1A1SMN1; SMN2MAPTALOX15KMT2A | |
| SCHEMBL18394780 | 0.69 | KDM4E (0.49) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL475555 | 0.68 | MRGPRX4 (0.54) | ALDH1A1SMN1; SMN2MAPTALOX15KMT2A | |
| SCHEMBL25256432 | 0.68 | GAA (0.55) | ALDH1A1MAPTALOX15KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |