Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964649 | 0.95 | TGFBR1 (0.41) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29964678 | 0.91 | MAPK1 (0.45) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29965004 | 0.90 | MAPK1 (0.42) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29965260 | 0.90 | MAPK1 (0.42) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL31079357 | 0.90 | MAPK1 (0.47) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL31079359 | 0.90 | CDK4 (0.40) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29964502 | 0.89 | MAPK1 (0.42) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29964856 | 0.89 | MAPKAPK2 (0.41) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL29964474 | 0.89 | MAPK1 (0.46) | CDK4CCND1CCND3CDK6MAPK1 | |
| SCHEMBL31079127 | 0.89 | MAPK1 (0.45) | CDK4CCND1CCND3CDK6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | CDK4 258/4885CCND1 970/4885CCND3 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.