Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964525 | 0.91 | MAPK1 (0.39) | MAPK1CDC7TLR9TLR8TLR7 | |
| SCHEMBL31079128 | 0.90 | MAPK1 (0.38) | MAPK1CDC7TLR9TLR8TLR7 | |
| SCHEMBL31079093 | 0.89 | MAPK1 (0.38) | MAPK1CDC7TLR9TLR8TLR7 | |
| SCHEMBL29963719 | 0.89 | HRH3 (0.44) | MAPK1CDC7MCHR1PARP1PARP2 | |
| SCHEMBL29965136 | 0.89 | ADORA2A (0.40) | MAPK1CDC7MCHR1PARP1PARP2 | |
| SCHEMBL29964120 | 0.87 | DRD2 (0.38) | MAPK1TLR9TLR8TLR7PARP1 | |
| SCHEMBL31079288 | 0.86 | MAPK1 (0.38) | MAPK1CDC7TLR9TLR8TLR7 | |
| SCHEMBL29964513 | 0.86 | CDC7 (0.35) | MAPK1CDC7MCHR1PARP1PARP2 | |
| SCHEMBL29964754 | 0.86 | MAPK1 (0.42) | MAPK1PARP1PARP2 | |
| SCHEMBL31079182 | 0.86 | MAPK1 (0.39) | MAPK1CDC7TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | MAPK1 141/4885CDC7 206/4885TLR9 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.