SCHEMBL31082489

SCHEMBL31082489

COC(=O)c1ccc(N2CCC(N(C(=O)OC(C)(C)C)C3CC3)CC2)c2cnc(OC)nc12

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 15/20 0.43
▸ CKS1B P61024 1/20 0.35
▸ SKP1 P63208 1/20 0.35
▸ SKP2 Q13309 1/20 0.35
▸ OPRK1 P41145 1/20 0.34
▸ AAK1 Q2M2I8 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ RPS6KB1 P23443 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31082538 0.92 GPR119 (0.44) GPR119CKS1BSKP1SKP2AAK1
SCHEMBL31082483 0.91 GPR119 (0.43) GPR119RPS6KB1
SCHEMBL31082410 0.88 GPR119 (0.39) GPR119CKS1BSKP1SKP2OPRK1
SCHEMBL31082343 0.87 GPR119 (0.44) GPR119CKS1BSKP1SKP2AAK1
SCHEMBL31082825 0.87 GPR119 (0.40) GPR119MAPT
SCHEMBL31082778 0.87 GPR119 (0.44) GPR119CKS1BSKP1SKP2AAK1
SCHEMBL31082602 0.85 RPS6KB1 (0.46) GPR119RPS6KB1
SCHEMBL31082842 0.81 GPR119 (0.46) GPR119CKS1BSKP1SKP2AAK1
SCHEMBL31210774 0.81 GPR119 (0.38) GPR119MAPT
SCHEMBL31210749 0.81 GPR119 (0.38) GPR119MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024182788-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 — — WO disclosed
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