Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3108310

Cc1cc(C)cc(P(c2cc(C)cc(C)c2)c2ccc3c(c2-c2c(P(c4cc(C)cc(C)c4)c4cc(C)cc(C)c4)ccc4c2OCO4)OCO3)c1.[Cl-].[Cl-].[Ru+2]

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 3/20 0.35
CYP19A1 P11511 2/20 0.35
HSP90AA1 P07900 2/20 0.33
HSP90AB1 P08238 2/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
ALDH1A1 P00352 4/20 0.32
KDM4E B2RXH2 2/20 0.32
MAPT P10636 2/20 0.32
KMT2A Q03164 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
MEN1 O00255 1/20 0.32
GMNN O75496 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
BLM P54132 1/20 0.32
CDC42 P60953 1/20 0.32
RAC1 P63000 1/20 0.32
PMP22 Q01453 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29565955 0.97 NQO2 (0.37) NQO2CYP19A1HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL698217 0.97 NQO2 (0.37) NQO2CYP19A1HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL29362227 0.97 NQO2 (0.37) NQO2CYP19A1HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL697978 0.84 HSP90AA1 (0.39) NQO2CYP19A1HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL6213387 0.84 ALDH1A1 (0.33) ALDH1A1KDM4EMAPTKMT2AMEN1
SCHEMBL14356056 0.84 HSP90AA1 (0.37) NQO2CYP19A1HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL18934246 0.83
SCHEMBL1144361 0.83 NQO2 (0.33) NQO2CYP19A1
SCHEMBL21500141 0.82
P-Cymene SCHEMBL30477519 0.81 ALDH1A1 (0.34) HSP90AA1HSP90AB1SMN1; SMN2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2264000-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL COMPOUND USING RUTHENIUM COMPOUND NIPPON SODA CO (JP) 2016-05-11 EP disclosed
US-8207379-B2 Ruthenium compound and method for producing optically active aminoalcohol compound NIPPON SODA CO., LTD. (JP) 2012-06-26 US disclosed
EP-2264000-A1 RUTHENIUM COMPOUND AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL COMPOUND Nippon Soda Co., Ltd. (JP) 2010-12-22 EP disclosed