Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BAX | Q07812 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655613 | 1.00 | MAPT (0.38) | MAPTPKMMAPK1CYP4F2CYP4A11 | |
| SCHEMBL25392327 | 0.83 | CYP4F2 (0.39) | MAPTCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL27338781 | 0.82 | MAPT (0.40) | MAPTCYP4F2CYP4A11KMT2AMEN1 | |
| SCHEMBL22655888 | 0.81 | RET (0.37) | CYP4F2CYP4A11RXRARXRBRXRG | |
| SCHEMBL31085415 | 0.81 | RET (0.37) | CYP4F2CYP4A11RXRARXRBRXRG | |
| SCHEMBL15744178 | 0.79 | CYP4F2 (0.39) | MAPTMAPK1CYP4F2CYP4A11RXRA | |
| SCHEMBL767404 | 0.79 | CYP4F2 (0.39) | MAPTMAPK1CYP4F2CYP4A11RXRA | |
| SCHEMBL2565958 | 0.78 | KMT2A (0.36) | MAPTCYP4F2CYP4A11RETKMT2A | |
| SCHEMBL30811764 | 0.78 | CYP4F2 (0.33) | CYP4F2CYP4A11RETKMT2AALDH1A1 | |
| SCHEMBL21797036 | 0.77 | RXRA (0.47) | MAPTPKMMAPK1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114096542-B | Condensed tricyclic pyrroles as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2024-09-10 | — | — | CN | disclosed |