Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108652 | 1.00 | SPHK2 (0.52) | SPHK2SPHK1MAOBPTPN1PTPN2 | |
| SCHEMBL3110254 | 0.93 | PPARD (0.51) | SPHK2SPHK1MAOBPTPN1PTPN2 | |
| SCHEMBL3110246 | 0.93 | PPARD (0.51) | SPHK2SPHK1MAOBPTPN1PTPN2 | |
| SCHEMBL3105501 | 0.93 | PPARD (0.56) | SPHK2SPHK1PTPN1PTPN2PTPN6 | |
| SCHEMBL3105508 | 0.93 | PPARD (0.56) | SPHK2SPHK1PTPN1PTPN2PTPN6 | |
| SCHEMBL3101525 | 0.92 | PPARD (0.45) | SPHK2SPHK1MAOBPTPN1PTPN6 | |
| SCHEMBL3101529 | 0.92 | PPARD (0.45) | SPHK2SPHK1MAOBPTPN1PTPN6 | |
| SCHEMBL3108834 | 0.91 | NR4A2 (0.54) | SPHK2SPHK1MAOBPTPN1PTPN6 | |
| SCHEMBL3108828 | 0.91 | NR4A2 (0.54) | SPHK2SPHK1MAOBPTPN1PTPN6 | |
| SCHEMBL3110948 | 0.90 | NR4A2 (0.54) | SPHK2SPHK1PPARDPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | WYETH (US) | 2008-12-18 | — | — | US | claimed |
| US-20060247298-A1 | Substituted acetic acid derivatives | WYETH (US) | 2006-11-02 | — | — | US | claimed |
| US-7803835-B2 | Substituted acetic acid derivatives | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
| US-7411083-B2 | Substituted acetic acid derivatives | WYETH (US) | 2008-08-12 | — | — | US | disclosed |
| US-20060247298-A1 | Substituted acetic acid derivatives | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312308-A1 | SUBSTITUTED ACETIC ACID DERIVATIVES | AADAC, ACACA, AANAT | SPHK2 2682/4885SPHK1 3532/4885MAOB 292/4885 |
| US-20060247298-A1 | Substituted acetic acid derivatives | AADAC, ACACA, AANAT | SPHK2 2682/4885SPHK1 3532/4885MAOB 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.