Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114047 | 0.90 | NLRP3 (0.46) | NLRP3TP53MAPTKDM4EHTT | |
| SCHEMBL3123719 | 0.89 | KDM4E (0.53) | NLRP3TP53MAPTKDM4EHTT | |
| SCHEMBL3119805 | 0.85 | KDM4E (0.46) | NLRP3TP53MAPTKDM4EHTT | |
| SCHEMBL3123871 | 0.84 | KDM4E (0.50) | NLRP3MAPTKDM4EHTTLMNA | |
| SCHEMBL3118325 | 0.84 | KDM4E (0.45) | NLRP3TP53KDM4EHTTLMNA | |
| SCHEMBL3109169 | 0.84 | KDM4E (0.45) | NLRP3KDM4EHTTLMNANPSR1 | |
| SCHEMBL8233038 | 0.84 | NLRP3 (0.74) | NLRP3TP53MAPTKDM4EHTT | |
| SCHEMBL3119406 | 0.84 | ENPP2 (0.46) | NLRP3TP53KDM4EHTTLMNA | |
| SCHEMBL3124169 | 0.83 | KDM4E (0.48) | NLRP3MAPTKDM4EHTTLMNA | |
| SCHEMBL8024196 | 0.81 | TP53 (0.62) | TP53MAPTKDM4EHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501957-B2 | Benzimidazole compounds and their use as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2013-08-06 | — | — | US | disclosed |
| EP-2397471-A1 | Benzimidazole compounds and their use | China Medical University (TW) | 2011-12-21 | — | — | EP | disclosed |
| US-20100179147-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179147-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | H1-3, BAK1, HDAC1 | NLRP3 3243/4885TP53 91/4885MAPT 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.