Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22088317 | 1.00 | SCN9A (0.43) | SCN9AALDH1A1NPSR1TP53POLB | |
| SCHEMBL22089149 | 0.91 | SCN9A (0.42) | SCN9AALDH1A1TP53POLBLMNA | |
| SCHEMBL22034822 | 0.89 | GAA (0.44) | SCN9AALDH1A1NPSR1TP53POLB | |
| SCHEMBL29669273 | 0.86 | SCN9A (0.46) | SCN9AALDH1A1NPSR1TP53POLB | |
| SCHEMBL19631763 | 0.86 | SCN9A (0.46) | SCN9AALDH1A1TP53POLBMAPT | |
| SCHEMBL1095344 | 0.86 | SCN9A (0.46) | SCN9AALDH1A1NPSR1TP53POLB | |
| SCHEMBL20449150 | 0.86 | SCN9A (0.46) | SCN9AALDH1A1TP53POLBMAPT | |
| SCHEMBL20449236 | 0.85 | SCN9A (0.46) | SCN9AALDH1A1TP53POLBLMNA | |
| SCHEMBL28526642 | 0.85 | SCN9A (0.48) | SCN9AALDH1A1TP53GAAMEN1 | |
| SCHEMBL20449132 | 0.85 | SCN9A (0.45) | SCN9ATP53POLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4655291-A2 | N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS BACKGROUND | Merck Sharp & Dohme LLC (US) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024158653-A2 | N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS BACKGROUND | MERCK SHARP & DOHME LLC (US) | 2024-08-02 | — | — | WO | disclosed |