Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 2/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10214729 | 0.85 | ALDH1A1 (0.53) | KMOALDH1A1RARBPLA2G2ARARG | |
| SCHEMBL2285188 | 0.84 | KMO (0.79) | KMOALDH1A1RARBFTOTHRA | |
| SCHEMBL31748479 | 0.81 | ALDH1A1 (0.49) | KMOALDH1A1RARBRARG | |
| SCHEMBL2731718 | 0.81 | ALDH1A1 (0.49) | KMOALDH1A1RARBPLA2G2ARARG | |
| SCHEMBL22067719 | 0.79 | ALDH1A1 (0.50) | ALDH1A1RARBRARG | |
| SCHEMBL14740028 | 0.77 | MAPT (0.46) | ALDH1A1RARBNPC1RAB9A | |
| SCHEMBL2963261 | 0.76 | ALDH1A1 (0.61) | ALDH1A1RARBPLA2G2ARARG | |
| SCHEMBL18603158 | 0.76 | ALDH1A1 (0.57) | KMOALDH1A1RARBPLA2G2APDE5A | |
| SCHEMBL18603139 | 0.76 | ALDH1A1 (0.49) | KMOALDH1A1RARBRARG | |
| SCHEMBL12900249 | 0.76 | ALDH1A1 (0.56) | KMOALDH1A1RARBTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024192146-A2 | COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS | SOUTHERN RESEARCH INSTITUTE (US) | 2024-09-19 | — | — | WO | disclosed |