Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31207261 | 1.00 | POLB (0.39) | POLBMEN1KMT2APABPC1ALDH1A1 | |
| SCHEMBL24853905 | 0.93 | MEN1 (0.40) | POLBMEN1KMT2APABPC1ALDH1A1 | |
| SCHEMBL31099062 | 0.93 | MEN1 (0.40) | POLBMEN1KMT2APABPC1ALDH1A1 | |
| SCHEMBL31207282 | 0.81 | NNMT (0.37) | POLBMEN1KMT2APABPC1ALDH1A1 | |
| SCHEMBL30318808 | 0.76 | CNR2 (0.40) | POLBMEN1KMT2APABPC1RAB9A | |
| SCHEMBL24094506 | 0.76 | CNR2 (0.40) | POLBMEN1KMT2APABPC1RAB9A | |
| SCHEMBL29002106 | 0.75 | GPBAR1 (0.37) | POLBMEN1KMT2AMAPK10 | |
| SCHEMBL24853925 | 0.74 | KMT2A (0.41) | MEN1KMT2APABPC1ALDH1A1CXCR1 | |
| SCHEMBL30318801 | 0.69 | NNMT (0.38) | POLBMEN1KMT2APABPC1NPC1 | |
| SCHEMBL29002114 | 0.68 | MEN1 (0.41) | POLBMEN1KMT2APABPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |