SCHEMBL3110718

SCHEMBL3110718

BrCc1cccc(Cc2cccc(C(Br)c3ccccn3)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 5/20 0.39
SLC6A4 P31645 5/20 0.39
SLC6A3 Q01959 4/20 0.39
CHRM2 P08172 3/20 0.35
SCN1A P35498 2/20 0.35
SCN2A Q99250 2/20 0.35
SCN3A Q9NY46 2/20 0.35
ALDH1A1 P00352 4/20 0.34
CYP1A2 P05177 1/20 0.34
KCNH2 Q12809 4/20 0.34
CYP2D6 P10635 2/20 0.34
CYP3A4 P08684 1/20 0.34
SLC10A1 Q14973 1/20 0.33
TSHR P16473 2/20 0.33
HSD17B10 Q99714 1/20 0.32
NPSR1 Q6W5P4 2/20 0.32
KDM4E B2RXH2 1/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TRPA1 O75762 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3094564 0.81 SLC6A3 (0.58) SLC6A2SLC6A4SLC6A3CHRM2SCN1A
SCHEMBL3103812 0.74 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3CHRM2ALDH1A1
SCHEMBL4316276 0.73 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3CHRM2SCN1A
SCHEMBL3111831 0.72 CYP19A1 (0.32) SLC6A4SLC6A3ALDH1A1TSHRTRPA1
SCHEMBL3103275 0.72 SLC5A2 (0.33) SLC6A2SLC6A4SLC6A3ALDH1A1CYP2D6
SCHEMBL11719471 0.72 SLC6A2 (0.46) SLC6A2SLC6A4SLC6A3CHRM2SCN1A
SCHEMBL15389994 0.71 TRPA1 (0.52) ALDH1A1CYP1A2TSHRTRPA1
SCHEMBL7556197 0.69 TRPA1 (0.59) ALDH1A1TSHRTRPA1
SCHEMBL3049830 0.69 SLC6A2 (0.54) SLC6A2SLC6A4SLC6A3CHRM2SCN1A
SCHEMBL29914092 0.69 SLC6A2 (0.54) SLC6A2SLC6A4SLC6A3CHRM2SCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2163553-B1 ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO LTD (CN) 2013-12-25 EP disclosed
EP-2163553-A1 ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF Beijing Molecule Science and Technology Co., Ltd. (CN) 2010-03-17 EP disclosed