Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.54 |
| ▸ | CHUK | O15111 | 5/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 10/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28875172 | 0.84 | ACVR1 (0.64) | IKBKBCHUKFLT3CITACVR1 | |
| SCHEMBL31473469 | 0.84 | ACVR1 (0.64) | IKBKBCHUKFLT3CITACVR1 | |
| SCHEMBL30009207 | 0.83 | JAK1 (0.53) | IKBKBCHUKCITNEK1 | |
| SCHEMBL31473445 | 0.80 | ROCK2 (0.65) | IKBKBCHUKFLT3CITACVR1 | |
| SCHEMBL4830288 | 0.80 | NEK1 (0.58) | IKBKBCHUKCITACVR1BMPR1B | |
| SCHEMBL1718719 | 0.78 | FLT3 (0.51) | FLT3CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL858202 | 0.76 | IKBKB (0.74) | IKBKBCHUKCITACVR1NEK1 | |
| SCHEMBL857035 | 0.75 | IKBKB (0.64) | IKBKBCHUKCITACVR1NEK1 | |
| SCHEMBL14493856 | 0.75 | FLT3 (0.53) | FLT3CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL4873430 | 0.74 | IKBKB (0.60) | IKBKBCHUKFLT3CITACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294522-A1 | 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS | LEAD DISCOVERY CENTER GMBH (DE) | 2024-09-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294522-A1 | 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS | GRK5, GRK3, GRK4 | IKBKB 696/4885CHUK 406/4885FLT3 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.