Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28695431 | 0.90 | MAPT (0.53) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL24379384 | 0.90 | MAPT (0.55) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL30952688 | 0.88 | MAPT (0.55) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL21682956 | 0.87 | MAPT (0.55) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL25232046 | 0.87 | MAPT (0.52) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12333908 | 0.85 | MAPT (0.53) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL30952684 | 0.85 | GPR119 (0.45) | MEN1KMT2AGPR119NR1H2NR1H3 | |
| SCHEMBL20046718 | 0.85 | MAPT (0.50) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL25447362 | 0.84 | MAPT (0.60) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL21876553 | 0.84 | MAPT (0.52) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024215817-A1 | NOVEL 5-CYCLOPROYLQUINOLINE DERIVATIVES AS PLPRO INHIBITORS | PFIZER INC. (US) | 2024-10-17 | — | — | WO | disclosed |