Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ACSL1 | P33121 | 2/20 | 0.50 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542790 | 0.93 | ACSL1 (0.59) | LMNAACSL1ACSL6KDM4EALDH1A1 | |
| SCHEMBL10452813 | 0.87 | KDM4E (0.60) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL10893810 | 0.87 | ACSL1 (0.61) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL10453813 | 0.86 | KDM4E (0.59) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL10453814 | 0.86 | KDM4E (0.59) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL9352912 | 0.84 | ACSL1 (0.53) | LMNAACSL1ACSL6KDM4EALDH1A1 | |
| SCHEMBL10454273 | 0.81 | ACSL1 (0.61) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL10627793 | 0.81 | ABCG2 (0.58) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10454185 | 0.81 | KDM4E (0.56) | ACSL1ACSL6KDM4EALDH1A1HPGD | |
| SCHEMBL10454119 | 0.80 | ACSL1 (0.60) | ACSL1ACSL6KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056600-A1 | 11BETA-HSD1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC | 2010-03-04 | — | — | US | claimed |
| EP-2141990-A1 | 11BETA-HSD1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119017-A1 | 11BETA-HSD1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-10-02 | — | — | WO | claimed |
| US-20100056600-A1 | 11BETA-HSD1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056600-A1 | 11BETA-HSD1 ACTIVE COMPOUNDS | HSD11B1, HSD3B1, HSD11B2 | LMNA 2280/4885ACSL1 231/4885ACSL6 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.