Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528060 | 1.00 | PDE4B (0.57) | PDE4BGPR119TP53MAPTKDM4E | |
| SCHEMBL1439746 | 0.94 | PDE4B (0.51) | PDE4BGPR119NR1H2USP30HPGDS | |
| SCHEMBL835855 | 0.93 | GPR119 (0.54) | PDE4BGPR119MAPTKDM4ETHRB | |
| SCHEMBL30376009 | 0.93 | GPR119 (0.54) | PDE4BGPR119MAPTKDM4ETHRB | |
| SCHEMBL4189282 | 0.90 | NR1H2 (0.48) | PDE4BGPR119TP53MAPTKDM4E | |
| SCHEMBL12320994 | 0.86 | GPR119 (0.59) | PDE4BGPR119TP53MAPTKDM4E | |
| SCHEMBL22608979 | 0.86 | PDE4B (0.58) | PDE4BGPR119TP53MAPTKDM4E | |
| SCHEMBL29880399 | 0.86 | GPR119 (0.59) | PDE4BGPR119TP53MAPTKDM4E | |
| SCHEMBL1546194 | 0.86 | PDE4B (0.56) | PDE4BTP53MAPTLMNA | |
| SCHEMBL29880252 | 0.86 | PDE4B (0.58) | PDE4BGPR119TP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |