Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | DRD5 | P21918 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031537 | 0.94 | SIGMAR1 (0.54) | PDE4BDRD3DRD2DRD4SIGMAR1 | |
| SCHEMBL30673157 | 0.92 | NAMPT (0.54) | PDE4BDRD3DRD2MAPTKDM4E | |
| SCHEMBL1558412 | 0.92 | NAMPT (0.54) | PDE4BDRD3DRD2MAPTKDM4E | |
| SCHEMBL12320994 | 0.88 | GPR119 (0.59) | PDE4BDRD3DRD2MAPTTP53 | |
| SCHEMBL29880399 | 0.88 | GPR119 (0.59) | PDE4BDRD3DRD2MAPTTP53 | |
| SCHEMBL31158869 | 0.86 | PDE4B (0.57) | PDE4BMAPTTP53KDM4ETHRB | |
| SCHEMBL19865015 | 0.86 | PDE4B (0.57) | PDE4BMAPTTP53KDM4ETHRB | |
| SCHEMBL31158950 | 0.86 | PDE4B (0.57) | PDE4BMAPTTP53KDM4ETHRB | |
| SCHEMBL20531395 | 0.86 | PDE4B (0.57) | PDE4BMAPTTP53KDM4ETHRB | |
| SCHEMBL528060 | 0.86 | PDE4B (0.57) | PDE4BMAPTTP53KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109956931-B | Tetrahydropyrrole compound, preparation method thereof, pharmaceutical composition and application thereof | 迈第康(上海)生物医药科技有限公司 | 2021-07-16 | — | — | CN | disclosed |
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | MEDICONNS SHANGHAI BIOPHARMACEUTICAL CO LTD (CN) | 2021-01-28 | — | — | US | disclosed |
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | MEDICONNS SHANGHAI BIOPHARMACEUTICAL CO LTD (CN) | 2021-01-28 | — | — | US | disclosed |
| CN-111978294-A | Preparation method of tetrahydropyrrole compound | 迈第康(上海)生物医药科技有限公司 | 2020-11-24 | — | — | CN | disclosed |
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |
| CN-109956931-A | Tetrahydropyrrole compound, preparation method, pharmaceutical composition and purposes | 迈第康(上海)生物医药科技有限公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-1859914-A | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO INC (US) | 2006-11-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | PRLHR, DRD2, AVPR2 | PDE4B 616/4885DRD3 38/4885DRD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.